???????? ??? ?????????????? ?? ??? ????? ?? ?? ?????????? ?? ?????? ?? ????????? ?? ???????.??????? ????????? ? ??? ?????? ???? ??????? ???????? ??? ?? ????????? ?? ?? ???? ??? ?????? ???? ? ????? ????.??????? ????: ??????? ?? ??? ??? ??? ??? ?????? ????? ???? ???.On the other hand, they did assist to ascertain basic safety parameters for administe